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KMID : 0914820060060020091
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Journal of the Korean Gastric Cancer Association
2006 Volume.6 No. 2 p.91 ~ p.96
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Apoptosis and Cell Proliferation in Gastric Adenoma and Adenocarcinoma
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Lee Dong-Soo
Kang Sang-Bum
Lee Seung-Woo
Nam Soon-Woo
You Young-Kyoung
Han Sok-Won
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Abstract
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Purpose: Cancer is a genetic disease caused by alterations in key regulators of cell growth and cell turnover. We investigated apoptotic cell death and cell proliferation in gastric adenomas and adenocarcinomas.
Materials and Methods: The TdT-mediated dUTP-biotin nick end labelling (TUNEL) method and immunohistochemistry for Ki-67 were performed, using paraffin-embedded tissues of 41 gastric adenomas and 100 gastric adenocarcinomas. These results were compared with histopathologic parameters.
Results: The Ki-67 labelling index was higher in adenocarcinomas than in adenomas and the apoptotic index was higher in adenomas than in adenocarcinomas. There were no significant difference between the apoptotic index/Ki-67 labelling index and clinicopathological parameters.
Conclusion: We propose that cell proliferation is more closely associated with gastric adenocarcinomas than apoptosis is, but that neither has any clinical significance as a prognostic factor in gastric adenocarcinomas. (J Korean Gastric Cancer Assoc 2006;6:91-96)
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KEYWORD
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Apoptosis, Cell proliferation, Gastric adenocarcionoma, Gastric adenoma
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